Rotundine

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Rotundine is a type of organic alkaloid with analgesic activity extracted from traditional Chinese medicine called Corydalis rhizoma. It has been used in a lot of countries as an alternative to anxiety and sedative drugs in the benzodiazepine group and analgesics such as opiates. Rotundine (l-THP) possesses a blocking effect on dopamine D1, D2, and D3 receptors and can inhibit physical dependence in morphine-dependent mice and significantly reduce the development of the conditional place preference induced by morphine in mice. On day 1 and 7, there is no difference in locomotor counts between the Rotundine groups (6.25, 12.5, and 18.75 mg/kg) and saline group [F(3, 37)=1.360, P>0.05, F(3, 37)=0.348, P>0.05, respectively].

Locomotor counts are greatly increased in the oxycodone group compared with the saline group. Rotundine at doses of 6.25, 12.5, and 18.75 mg/kg antagonizes hyperactivity induced by oxycodone. Rotundine has a protective effect on liver injury caused by muscle carbon technology, With analgesia and sedative-hypnotic activity, it can depress the persistent chtonic pain and dull pain. Rotundine has the effect of promoting blood circulation by removing blood stasis and promoting circulation of qi to relieve pain. Rotundine is commonly used for hypochondriac pain due to stagnation of the liver-qi, stomachache due to extraordination of the stomach-qi, the ernial pain.

Rotundine has the effect of regulating the heart rate, lowering blood pressure, and relaxing smooth muscles, so it reduces the pain caused by spasms of the digestive tract and uterus. This drug is also used to treat asthma or hiccups thanks to its respiratory conditioning effect. Due to the pronounced neuroleptic effect on the peristalsis, Rotundine can be used to treat cases of increased peristalsis and jerky gastrointestinal tract.

Formula: C21H25NO4

CAS Number: 10097-84-4

Molecular Weight: 355.43

Purity: 99.8% 

Appearance: Solid

Research Chemicals are available in Crystalline solid, crystal, powder, and liquid form

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