Huperzine A

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Huperzine A is an acetylcholinesterase inhibitor. It is known for enhancing learning and memory by protecting a neurotransmitter molecule in the brain. Huperzine is also a NMDA glutamate receptor antagonist (1-2). The effects on the treatment of Alzheimer’s disease is under studies. Recent studies of Huperzine A highlight the potential therapeutic use for dementia by slowing down the neuronal cell death caused by glutamate.

Huperzine A was isolated from the club moss Huperzia serrata (Thunb.) Trev., also known as Lycopodium serratum Thunb, and was found to be a potent inhibitor of acetyl cholinesterase (AChE) with significant selectivity for AChE over butyrylcholinesterase. Since AD is characterized by cholinergic dysfunction resulting from a deficiency of the neurotransmitter acetylcholine, AChE inhibitors play a major role in the treatment of this devastating disease. Currently used AChE inhibitors include tacrine, donepezil (Aricept), rivastigmine, galanthamine, and memantine.

The biological effects of huperzine A have been reviewed on several occasions and the compound is currently in clinical trials for the treatment of AD. A review of these trials states, “Thus, it appears that HupA (huperzine A) is more effective than other drugs that affect the cholinergic system and that are currently on the market in the USA for the treatment of mild to moderate AD. Because HupA was discovered in China during the years just after the Cultural Revolution, however, no patents were filed and all of this information rests in the public domain, rendering HupA non-viable as a commercially developable drug.”

Formula: C15H18N2O

CAS Number: 102518-79-6

Molecular Weight: 242.32

Purity: 99.8% 

Appearance: Solid

Research Chemicals are available in Crystalline solid, solid, crystal, powder, and liquid form

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