Huperzine B

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Huperzine-B is an efficient inhibitor of human brain AChE. 2. Huperzine-B can enhance ognitive and protect neuro, maybe potential new drug candidates for Alzheimer's disease therapy. Huperzine B was synthesized through chemical reactions. The inhibitory activities of the derivatives toward AChE and butyrylcholinesterase (BuChE) were determined in vitro by modified Ellman's method. Cell viability was quantified by the reduction of MTT.

A new preparative method was developed for the generation of 16-substituted derivatives of Huperzine B, and pharmacological trials indicated that the derivatives were multifunctional cholinesterase inhibitors targeting both AChE and BuChE. Among the derivatives tested, 9c, 9e, 9f, and 9i were 480 to 1360 times more potent as AChE inhibitors and 370 to 1560 times more potent as BuChE inhibitors than the parent Huperzine B.

Further preliminary pharmacological trials of derivatives 9c and 9i were performed, including examining the mechanism of AChE inhibition, the substrate kinetics of the enzyme inhibition, and protection against hydrogen peroxide (H2O2)-induced cytotoxicity in PC12 cells. 

Formula: C16H20N2O

CAS Number: 103548-82-9

Molecular Weight: 256.34

Purity: 99.8% 

Appearance: Solid

Research Chemicals are available in Crystalline solid, solid, crystal, powder, and liquid form

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